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The Peter Attia Drive

Peter Attia, MD

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The Peter Attia Drive

The Peter Attia Drive

Peter Attia, MD

1.1K
Followers
14.2K
Plays
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About Us

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

Latest Episodes

Lori Gottlieb: Understanding pain, therapeutic breakthroughs, and keys to enduring emotional health

Lori Gottlieb is a psychotherapist and the bestselling author of Maybe You Should Talk to Someone. In this episode, Lori extracts important lessons from her experiences as both a therapist and a patient. The stories Lori shares has provided her the material for insights into living a more fulfilling life. In our conversation, Lori also dispels some misconceptions about therapy, explains the process of big therapeutic breakthroughs, and reveals the most important steps for enduring emotional health. We discuss: Lori’s unique path to becoming a therapist [3:00]; Dissecting cadavers—a profound experience during med school [12:30]; The sunk cost fallacy—How Lori was able to walk away from med school [17:15]; Being aware of the gift of life, and other lessons from Lori’s terminally ill patient [24:00]; How underlying pain can manifest in obnoxious behavior [32:45]; Counseling versus therapy [36:15]; The story of John—why men hide their feelings, breaking down his shield, and uncovering his pain [38:30]; “Breaking open”—A shocking revelation about John that tests Lori’s resolve as a therapist [46:30]; Rewriting your story, the recovery process, and the most important step for lasting change [49:00]; The process of many big therapeutic breakthroughs [56:00]; The 2 types of suicidal thoughts, and the importance of talking about it [1:01:00]; The most common issues that bring patients to therapy with Lori [1:02:45]; Clinging to the familiar—why change is so hard [1:05:15]; A story of shame, lack of self-compassion, and self-sabotage [1:07:00]; The importance of managing mental health to reduce unnecessary suffering [1:15:45]; Dispelling the misconceptions about therapy [1:23:15]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/LoriGottlieb Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

90 MIN1 d ago
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Lori Gottlieb: Understanding pain, therapeutic breakthroughs, and keys to enduring emotional health

Azra Raza, M.D.: Why we're losing the war on cancer

Azra Raza is a physician, scientist, author, and outspoken advocate for reconfiguring the current model of research in cancer. In this episode, Azra discusses the content of her book, The First Cell, which takes a critical look at the outdated models being used to study cancer resulting in a lack of progress in survival rates for cancer patients. Azra offers a solution which focuses on early detection and prevention, and she concludes with an optimistic outlook for the future of cancer research. We discuss: Azra’s upbringing, interest in oncology, and the basis for writing her book [3:30]; The lack of progress in cancer treatment over the decades [18:45]; What is holding the oncology field back? [33:15]; Do the purported advances in oncology reflect the billions of dollars spent on cancer research? [40:00]; Economics of new cancer drugs—how small increases in survival come with staggering financial burdens [47:00]; How good intentions can still lead to misaligned incentives and a broken system [1:03:00]; Why 95% of new cancer drugs fail—a critical review of the cancer research model [1:11:15]; Early detection and prevention—a potential solution to the cancer problem [1:22:30]; Coping with the loss of her husband to cancer [1:46:00]; Azra’s optimistic view of the future [1:49:30]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/azraraza Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

114 MIN1 w ago
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Azra Raza, M.D.: Why we're losing the war on cancer

AMA with Dom D’Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health

In part 2 of this special AMA episode, ketosis expert Dom D’Agostino once again joins Bob Kaplan, Peter’s Head of Research, to discuss the impact of ketosis on various chronic diseases as well as the latest research on the metabolic management of cancer. Dom also discusses the numerous applications of hyperbaric oxygen therapy, provides insights into the application of ketosis on female health and performance, and much more. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on yourprivate RSS feedor on the websiteshow notes page. We discuss: Update on Dom’s Press-pulse therapeutic strategy for the metabolic management of cancer [2:05]; Potential role for vitamin C in cancer treatment [12:45]; Glutamine targeting in cancer therapy—evidence that the mitochondria in cancer are damaged? [17:45]; Can a ketogenic diet lessen the toxicity of cancer therapies? [24:45]; 3BP—a promising agent in cancer therapy [26:45]; The relationship between cancer and ketogenic diets [29:30]; Hyperbaric oxygen therapy (HBOT)—primer, protocols, and therapeutic uses [33:30]; Is there a potential role for HBOT in treating COVID-19 patients? [44:15]; Non-cancer applications of HBOT [47:30]; The inverse relationship between glucose and ketones [50:30]; Is a ketogenic diet appropriate for type 1 diabetics? [54:00]; How ketosis may reduce the risk for Alzheimer’s disease and Parkinson’s disease [1:00:30]; Ketosis for females—considerations, fertility, performance, and the latest research [1:11:00]; Low-carb diets during pregnancy and postpartum [1:17:00]; A high-protein diet to counteract common hormonal issues associated with the ketogenic diet [1:21:15]; Nutritional tips for remaining metabolically flexible [1:22:45]; What is one belief Dom has changed his mind about? [1:26:45]; In utero experiments, and other interesting questions Dom wants to explore [1:29:45]; The anti-catabolic effect of ketones, cancer cachexia, and nutritional interventions for cancer patients [1:38:30]; What is the one interesting experiment Dom would do if money and time were not a barrier? [1:46:25]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/domdagostinoama02/ Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

28 MIN2 w ago
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AMA with Dom D’Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health

Terry Real: Breaking the cycle of shame, anger, and depression

Terry Real, a renowned family therapist and best-selling author, helps people create the connections they desire in their relationships. In this episode, Terry describes how his upbringing with an abusive father forged his path to become a therapist, develop his Relational Life Therapy (RLT) framework, and writeI Don't Want to Talk About It—a book that reveals the hidden legacy of male depression. Terry discusses the link between childhood trauma and the deep-rooted shame, anger, and depression, which can result in feeling disconnected. Using real-life examples, Terry explains how he implements RLT to confront trauma, discover its origin, and teach the skills to break the cycle of pain, in order to live a satisfying life. We discuss: Terry’s upbringing with a depressed and abusive father [3:15]; The importance of the repair process, after relational disharmony, to break the trauma cycle [15:15]; The impact of a patriarchal society, and relational growth as the next step for feminism [19:00]; Origins of deep-rooted shame, and the difference between feeling ashamed and feeling guilty [27:15]; Preventing the propagation of trauma without over-coddling kids [35:30]; The one-up/one-down cycle from grandiosity to shame [37:30]; Covert depression—Steps to fixing the secret legacy of male depression [40:00]; Three forms of false self-esteem [50:00]; Narcissism—A misunderstood concept [51:45]; The interplay of shame, anger, and grandiosity, and how to break the cycle [54:15]; The Relational Life Therapy framework [1:06:30]; How the adaptive child becomes the maladaptive adult [1:15:30]; Speaking the language of social relationships [1:21:45]; When does it make sense for a couple to separate? [1:26:30]; Witness abuse—Consequences of screaming at your partner in the presence of children [1:28:15]; Cases of instantaneous change, and other behavioral changes that may take more time [1:30:45]; Reconciling with his father—Terry’s final conversation with his dad [1:33:45]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/terryreal Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

99 MIN3 w ago
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Terry Real: Breaking the cycle of shame, anger, and depression

Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging

Lloyd Klickstein is the Chief Science Officer at resTORbio, a biopharmaceutical company that develops medications to target the biology of aging. In this episode, Lloyd discusses his company’s clinical application of rapamycin and its derivatives. He also elucidates details of his 2014 paper—a paper that greatly influenced Peter’s perspective of rapamycin in the context of longevity. Peter and Lloyd go on to discuss the dose-dependent effect of rapamycin on immune function and compare rapamycin, fasting, and caloric restriction. We discuss: His background and decision to leave academia for translational medicine [6:15]; Translational medicine—bridging the gap between basic science and clinical medicine [10:30]; What prompted Lloyd to focus on mTOR inhibition? [18:00]; Defining mTOR, TORC1, and TORC2, and the consequences of inhibiting them with rapamycin [21:30]; Dose-dependent impact of rapamycin on immune function, mTOR inhibition, and toxicity [42:15]; Lloyd’s 2014 experiment—mTOR inhibition improves immune function in the elderly [53:00]; Insights into autophagy, antigen presentation, and the pleiotropic benefits of a rapalog, and how it compares to fasting [1:13:00]; Lloyd’s 2018 experiment—TORC1 inhibition enhances immune function and reduces infections in the elderly [1:18:45]; Creation of resTORbio, subsequent studies, and takeaways about dosing, TORC2 inhibition, and tissue selectivity [1:29:00]; Comparing the longevity effect of rapamycin, fasting, and caloric restriction [1:40:00]; Excitement around RTB101—resTORbio’s mTOR inhibiting molecule [1:47:00]; Identifying rapalogs selective for TORC1 [1:56:15]; Treating depression with ketamine, an activator of mTOR [2:00:00]; Epigenetic clocks, rapalogs, and metformin [2:03:30]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/LloydKlickstein Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

134 MINJUL 6
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Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging

Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19

In this episode, Stanley Perlman shares insights from his impressive career studying coronaviruses—both the common and more deadly ones, like MERS and SARS. In comparing preceding coronaviruses with SARS-CoV-2, Stanley discusses how other coronaviruses can aid our current understanding of, and be used to infer about, COVID-19. He also gives his thoughts on durable immunity, therapeutic strategies, and future outbreak preparedness. We discuss: His background and early work with coronaviruses [2:45]; The coronavirus family—various types, common traits, and scientific understanding [9:00]; The origin of viruses, animal to human transmission, R_0, immunity, and more [17:45]; Insights from the 2002 SARS outbreak [28:30]; Insights from the 2012 MERS outbreak [35:00]; Comparing SARS-CoV-2 to MERS, SARS, and other coronaviruses [42:00]; COVID-19 survivor potential for long-term damage [53:30]; Using the current pandemic for lessons on future preparedness [57:00]; Genetic drift and the potential for long-term immunity to COVID-19 [1:07:00]; Prevention and treatment strategies for COVID-19 and future diseases [1:22:30]; Alternative hypothesis to the origin of SARS-CoV-2 [1:32:30]; Determining durable immunity to COVID-19 and what a successful vaccine looks like [1:34:30]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/stanleyperlman Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

103 MINJUN 29
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Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19

AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise

Back by very popular demand for a special AMA episode, ketosis expert Dom D’Agostino joins Bob Kaplan, Peter’s Head of Research, to address many lingering questions about the ketogenic diet, exogenous ketones, and exercise for overall health. Dom also shares valuable insights from his personal experience with training, supplements, intermittent fasting, and other nutritional strategies to optimize his own health and performance. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA.If you’re a subscriber, you can now listen to this full episode on yourprivate RSS feedor on the website show notes page. We discuss: Dom’s recent and ongoing projects [3:00]; Benefits of a ketogenic diet for an otherwise healthy person [7:00]; Book recommendations to become more knowledgeable about a ketogenic diet [11:30]; Best devices for measuring ketones [13:45]; Genetic factors that influence how someone responds to the ketogenic diet [24:45]; Ketogenic diet for those with the APOE e4 allele [28:15]; Impact of long-term ketogenic diets on thyroid function [34:25]; Low-carb and ketogenic diets for appetite control and weight management [39:00]; Ketogenic diet and the microbiome [43:00]; Comparing monounsaturated fat versus saturated fat on the ketogenic diet [45:55]; Implications of long-term genetic and epigenetic adaptations to a ketogenic diet [47:45]; Why some people see a rise in LDL-C and LDL-P when on a ketogenic diet and what they can do about it [50:15]; Should someone with familial hypercholesterolemia consider a ketogenic diet? [55:00]; Exogenous ketones—benefits, therapeutic uses, and ketone supplements that Dom has tested [56:45]; Ketogenic protocols for management of traumatic brain injuries [1:06:00]; Comparing the benefits and therapeutic uses of various medium-chain fatty acids—caprylic acid (C8), capric acid (C10), MCT oil, and coconut oil [1:08:45]; Nootropics, caffeine, and other stimulants [1:16:15]; Supplemental use of testosterone, DHEA, and creatine for muscle growth and performance [1:23:45]; Impact of fasted-state training on strength and performance [1:30:15]; Stacking exogenous ketones with MCTs for optimal effectiveness [1:33:30]; BCAA supplements during a fast for muscle preservation [1:35:45]; What app is Dom using to track his macros? [1:42:00]; Getting enough micronutrients while on a ketogenic diet [1:47:15]; Ideal macros and getting enough protein for strength training in ketosis [1:48:15]; Pros, cons, and ideal macros of one meal a day [1:51:15]; Dom’s take on “carb backloading” [1:54:45]; Dom’s take on “carb up” days for ketogenic dieters [2:01:00]; Dom’s thoughts on the carnivore diet and the paleolithic ketogenic diet [2:05:30]; Advantages of the ketogenic diet for extreme endurance athletes [2:10:30]; Impact on strength, power, and performance during the adaptation period of the ketogenic diet [2:14:00]; Fasted-state elevation in growth hormone and its impact on training [2:17:45]; Is it possible to build muscle on a ketogenic diet? [2:23:30]; Why Dom took a year off from weight training [2:28:00]; What does Dom do for cardio exercise? [2:30:45]; Protocols for hard training recovery [2:33:15]; Dom’s personal approach to fasting, time-restricted eating, and sleep [2:35:45]; People, books, and other resources that shaped Dom’s training and nutrition [2:38:45]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/domdagostinoama01 Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

28 MINJUN 22
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AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise

David Watkins, Ph.D.: A masterclass in immunology, monoclonal antibodies, and vaccine strategies for COVID-19

In this episode, David Watkins, professor of pathology at George Washington University, shares how insights from his HIV and Zika virus research could apply to SARS-CoV-2 protection strategies. David introduces monoclonal antibodies as an intervention to prevent and treat COVID-19 infection, and also discusses how they could be used as a hedge to vaccine development. Additionally, David’s immunology tutorial explains the innate and adaptive immune systems and their differentiated responses to viral infection. We discuss: Background and current interest in immunology [4:30]; Immunology 101—The innate and adaptive immune system [10:15]; Defining antibodies, importance of neutralizing antibodies, and serology testing for COVID-19 [19:00]; B cells—How they fight viruses, create antibodies, and fit into the vaccine strategy [25:00]; T cells—Role in the adaptive immune system and ability to kill infected cells to prevent viral spread [36:15]; Valuable lessons from HIV applied to SARS-CoV-2 [51:00]; Lessons taken from the hepatitis C success story [1:01:30]; Monoclonal antibodies, vaccines, and the most promising strategies for preventing and treating COVID-19 infection [1:04:45]; COVID-19 vaccines in development [1:19:00]; How David’s work with Zika virus informs his thinking on SARS-CoV-2 [1:25:20]; Why a vaccine for COVID-19 doesn’t need to be perfect to be effective [1:27:45]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/davidwatkins Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

97 MINJUN 15
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David Watkins, Ph.D.: A masterclass in immunology, monoclonal antibodies, and vaccine strategies for COVID-19

Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies

In this episode, Eileen White, Chief Scientific Officer at the Rutgers Cancer Institute, describes the fundamental role of autophagy in the maintenance of health and prevention of neurodegeneration, cancer, and other diseases. She also goes into detail about the paradoxical finding that autophagy may benefit an existing cancer cell and help it to survive—a discovery leading to new possibilities in cancer therapy. We also discuss fasting (and molecules that induce autophagy) and the critical need to decode the proper fasting “dose” in order to improve human health. We discuss: Eileen’s discovery thata specificoncogeneblocksapoptosis [3:40]; Defining apoptosis and its role in cancer prevention [10:00]; Howcancer cells use the autophagy pathway to survive [17:20]; Stressorsthat induce autophagy [29:15]; The importance of autophagy in the brain and liver[32:45]; The mechanisms that can trigger autophagy to support longevity[40:00]; Evidence for cancer treatment by blocking autophagy[42:30]; Types of cancer that are mostautophagy-dependent[46:45]; The autophagy paradox[52:40]; Finding a molecular signal for autophagy[59:15]; Current knowledge gaps around fasting as a tool for longevity[1:13:00]; Rapamycin, metformin, and other molecules that may induce autophagy[1:22:15]; How to study fasting and exercise as longevity tools[1:32:50]; The Nobel Prize for autophagy research[1:36:45]; Eileen’s future areas of research[1:38:25]; A fasting strategy for Alzheimer’s Disease prevention[1:49:25]; Future study of metabolism and autophagy[1:51:30]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/eileenwhite Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

118 MINJUN 8
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Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies

Normative errors—a conversation with my daughter about current events

In this episode, I sit down with my daughter to discuss the brutal death of George Floyd, and the aftermath we are watching unfold. Though I have no expertise in race relations, law enforcement, or police brutality, I do have some knowledge in the training of physicians, and it is that training of doctors that I’ve been thinking about lately as it may offer one small insight into this crisis. In this very short discussion, we speak about three types of errors in medicine (and medical training), how to distinguish between the two variants that are acceptable, and the one that is unacceptable. My question, ultimately, is if such a framework can be applied to law enforcement? Learn more:https://peterattiamd.com/ Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

22 MINJUN 4
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Normative errors—a conversation with my daughter about current events

Latest Episodes

Lori Gottlieb: Understanding pain, therapeutic breakthroughs, and keys to enduring emotional health

Lori Gottlieb is a psychotherapist and the bestselling author of Maybe You Should Talk to Someone. In this episode, Lori extracts important lessons from her experiences as both a therapist and a patient. The stories Lori shares has provided her the material for insights into living a more fulfilling life. In our conversation, Lori also dispels some misconceptions about therapy, explains the process of big therapeutic breakthroughs, and reveals the most important steps for enduring emotional health. We discuss: Lori’s unique path to becoming a therapist [3:00]; Dissecting cadavers—a profound experience during med school [12:30]; The sunk cost fallacy—How Lori was able to walk away from med school [17:15]; Being aware of the gift of life, and other lessons from Lori’s terminally ill patient [24:00]; How underlying pain can manifest in obnoxious behavior [32:45]; Counseling versus therapy [36:15]; The story of John—why men hide their feelings, breaking down his shield, and uncovering his pain [38:30]; “Breaking open”—A shocking revelation about John that tests Lori’s resolve as a therapist [46:30]; Rewriting your story, the recovery process, and the most important step for lasting change [49:00]; The process of many big therapeutic breakthroughs [56:00]; The 2 types of suicidal thoughts, and the importance of talking about it [1:01:00]; The most common issues that bring patients to therapy with Lori [1:02:45]; Clinging to the familiar—why change is so hard [1:05:15]; A story of shame, lack of self-compassion, and self-sabotage [1:07:00]; The importance of managing mental health to reduce unnecessary suffering [1:15:45]; Dispelling the misconceptions about therapy [1:23:15]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/LoriGottlieb Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

90 MIN1 d ago
Comments
Lori Gottlieb: Understanding pain, therapeutic breakthroughs, and keys to enduring emotional health

Azra Raza, M.D.: Why we're losing the war on cancer

Azra Raza is a physician, scientist, author, and outspoken advocate for reconfiguring the current model of research in cancer. In this episode, Azra discusses the content of her book, The First Cell, which takes a critical look at the outdated models being used to study cancer resulting in a lack of progress in survival rates for cancer patients. Azra offers a solution which focuses on early detection and prevention, and she concludes with an optimistic outlook for the future of cancer research. We discuss: Azra’s upbringing, interest in oncology, and the basis for writing her book [3:30]; The lack of progress in cancer treatment over the decades [18:45]; What is holding the oncology field back? [33:15]; Do the purported advances in oncology reflect the billions of dollars spent on cancer research? [40:00]; Economics of new cancer drugs—how small increases in survival come with staggering financial burdens [47:00]; How good intentions can still lead to misaligned incentives and a broken system [1:03:00]; Why 95% of new cancer drugs fail—a critical review of the cancer research model [1:11:15]; Early detection and prevention—a potential solution to the cancer problem [1:22:30]; Coping with the loss of her husband to cancer [1:46:00]; Azra’s optimistic view of the future [1:49:30]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/azraraza Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

114 MIN1 w ago
Comments
Azra Raza, M.D.: Why we're losing the war on cancer

AMA with Dom D’Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health

In part 2 of this special AMA episode, ketosis expert Dom D’Agostino once again joins Bob Kaplan, Peter’s Head of Research, to discuss the impact of ketosis on various chronic diseases as well as the latest research on the metabolic management of cancer. Dom also discusses the numerous applications of hyperbaric oxygen therapy, provides insights into the application of ketosis on female health and performance, and much more. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on yourprivate RSS feedor on the websiteshow notes page. We discuss: Update on Dom’s Press-pulse therapeutic strategy for the metabolic management of cancer [2:05]; Potential role for vitamin C in cancer treatment [12:45]; Glutamine targeting in cancer therapy—evidence that the mitochondria in cancer are damaged? [17:45]; Can a ketogenic diet lessen the toxicity of cancer therapies? [24:45]; 3BP—a promising agent in cancer therapy [26:45]; The relationship between cancer and ketogenic diets [29:30]; Hyperbaric oxygen therapy (HBOT)—primer, protocols, and therapeutic uses [33:30]; Is there a potential role for HBOT in treating COVID-19 patients? [44:15]; Non-cancer applications of HBOT [47:30]; The inverse relationship between glucose and ketones [50:30]; Is a ketogenic diet appropriate for type 1 diabetics? [54:00]; How ketosis may reduce the risk for Alzheimer’s disease and Parkinson’s disease [1:00:30]; Ketosis for females—considerations, fertility, performance, and the latest research [1:11:00]; Low-carb diets during pregnancy and postpartum [1:17:00]; A high-protein diet to counteract common hormonal issues associated with the ketogenic diet [1:21:15]; Nutritional tips for remaining metabolically flexible [1:22:45]; What is one belief Dom has changed his mind about? [1:26:45]; In utero experiments, and other interesting questions Dom wants to explore [1:29:45]; The anti-catabolic effect of ketones, cancer cachexia, and nutritional interventions for cancer patients [1:38:30]; What is the one interesting experiment Dom would do if money and time were not a barrier? [1:46:25]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/domdagostinoama02/ Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

28 MIN2 w ago
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AMA with Dom D’Agostino, Ph.D., Part II of II: Ketosis for cancer and chronic disease, hyperbaric oxygen therapy, and the effect of ketosis on female health

Terry Real: Breaking the cycle of shame, anger, and depression

Terry Real, a renowned family therapist and best-selling author, helps people create the connections they desire in their relationships. In this episode, Terry describes how his upbringing with an abusive father forged his path to become a therapist, develop his Relational Life Therapy (RLT) framework, and writeI Don't Want to Talk About It—a book that reveals the hidden legacy of male depression. Terry discusses the link between childhood trauma and the deep-rooted shame, anger, and depression, which can result in feeling disconnected. Using real-life examples, Terry explains how he implements RLT to confront trauma, discover its origin, and teach the skills to break the cycle of pain, in order to live a satisfying life. We discuss: Terry’s upbringing with a depressed and abusive father [3:15]; The importance of the repair process, after relational disharmony, to break the trauma cycle [15:15]; The impact of a patriarchal society, and relational growth as the next step for feminism [19:00]; Origins of deep-rooted shame, and the difference between feeling ashamed and feeling guilty [27:15]; Preventing the propagation of trauma without over-coddling kids [35:30]; The one-up/one-down cycle from grandiosity to shame [37:30]; Covert depression—Steps to fixing the secret legacy of male depression [40:00]; Three forms of false self-esteem [50:00]; Narcissism—A misunderstood concept [51:45]; The interplay of shame, anger, and grandiosity, and how to break the cycle [54:15]; The Relational Life Therapy framework [1:06:30]; How the adaptive child becomes the maladaptive adult [1:15:30]; Speaking the language of social relationships [1:21:45]; When does it make sense for a couple to separate? [1:26:30]; Witness abuse—Consequences of screaming at your partner in the presence of children [1:28:15]; Cases of instantaneous change, and other behavioral changes that may take more time [1:30:45]; Reconciling with his father—Terry’s final conversation with his dad [1:33:45]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/terryreal Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

99 MIN3 w ago
Comments
Terry Real: Breaking the cycle of shame, anger, and depression

Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging

Lloyd Klickstein is the Chief Science Officer at resTORbio, a biopharmaceutical company that develops medications to target the biology of aging. In this episode, Lloyd discusses his company’s clinical application of rapamycin and its derivatives. He also elucidates details of his 2014 paper—a paper that greatly influenced Peter’s perspective of rapamycin in the context of longevity. Peter and Lloyd go on to discuss the dose-dependent effect of rapamycin on immune function and compare rapamycin, fasting, and caloric restriction. We discuss: His background and decision to leave academia for translational medicine [6:15]; Translational medicine—bridging the gap between basic science and clinical medicine [10:30]; What prompted Lloyd to focus on mTOR inhibition? [18:00]; Defining mTOR, TORC1, and TORC2, and the consequences of inhibiting them with rapamycin [21:30]; Dose-dependent impact of rapamycin on immune function, mTOR inhibition, and toxicity [42:15]; Lloyd’s 2014 experiment—mTOR inhibition improves immune function in the elderly [53:00]; Insights into autophagy, antigen presentation, and the pleiotropic benefits of a rapalog, and how it compares to fasting [1:13:00]; Lloyd’s 2018 experiment—TORC1 inhibition enhances immune function and reduces infections in the elderly [1:18:45]; Creation of resTORbio, subsequent studies, and takeaways about dosing, TORC2 inhibition, and tissue selectivity [1:29:00]; Comparing the longevity effect of rapamycin, fasting, and caloric restriction [1:40:00]; Excitement around RTB101—resTORbio’s mTOR inhibiting molecule [1:47:00]; Identifying rapalogs selective for TORC1 [1:56:15]; Treating depression with ketamine, an activator of mTOR [2:00:00]; Epigenetic clocks, rapalogs, and metformin [2:03:30]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/LloydKlickstein Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

134 MINJUL 6
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Lloyd Klickstein, M.D., Ph.D.: Rapamycin, mTOR inhibition, and the biology of aging

Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19

In this episode, Stanley Perlman shares insights from his impressive career studying coronaviruses—both the common and more deadly ones, like MERS and SARS. In comparing preceding coronaviruses with SARS-CoV-2, Stanley discusses how other coronaviruses can aid our current understanding of, and be used to infer about, COVID-19. He also gives his thoughts on durable immunity, therapeutic strategies, and future outbreak preparedness. We discuss: His background and early work with coronaviruses [2:45]; The coronavirus family—various types, common traits, and scientific understanding [9:00]; The origin of viruses, animal to human transmission, R_0, immunity, and more [17:45]; Insights from the 2002 SARS outbreak [28:30]; Insights from the 2012 MERS outbreak [35:00]; Comparing SARS-CoV-2 to MERS, SARS, and other coronaviruses [42:00]; COVID-19 survivor potential for long-term damage [53:30]; Using the current pandemic for lessons on future preparedness [57:00]; Genetic drift and the potential for long-term immunity to COVID-19 [1:07:00]; Prevention and treatment strategies for COVID-19 and future diseases [1:22:30]; Alternative hypothesis to the origin of SARS-CoV-2 [1:32:30]; Determining durable immunity to COVID-19 and what a successful vaccine looks like [1:34:30]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/stanleyperlman Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

103 MINJUN 29
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Stanley Perlman, M.D., Ph.D.: Insights from a coronavirus expert on COVID-19

AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise

Back by very popular demand for a special AMA episode, ketosis expert Dom D’Agostino joins Bob Kaplan, Peter’s Head of Research, to address many lingering questions about the ketogenic diet, exogenous ketones, and exercise for overall health. Dom also shares valuable insights from his personal experience with training, supplements, intermittent fasting, and other nutritional strategies to optimize his own health and performance. If you’re not a subscriber and listening on a podcast player, you’ll only be able to hear a preview of the AMA.If you’re a subscriber, you can now listen to this full episode on yourprivate RSS feedor on the website show notes page. We discuss: Dom’s recent and ongoing projects [3:00]; Benefits of a ketogenic diet for an otherwise healthy person [7:00]; Book recommendations to become more knowledgeable about a ketogenic diet [11:30]; Best devices for measuring ketones [13:45]; Genetic factors that influence how someone responds to the ketogenic diet [24:45]; Ketogenic diet for those with the APOE e4 allele [28:15]; Impact of long-term ketogenic diets on thyroid function [34:25]; Low-carb and ketogenic diets for appetite control and weight management [39:00]; Ketogenic diet and the microbiome [43:00]; Comparing monounsaturated fat versus saturated fat on the ketogenic diet [45:55]; Implications of long-term genetic and epigenetic adaptations to a ketogenic diet [47:45]; Why some people see a rise in LDL-C and LDL-P when on a ketogenic diet and what they can do about it [50:15]; Should someone with familial hypercholesterolemia consider a ketogenic diet? [55:00]; Exogenous ketones—benefits, therapeutic uses, and ketone supplements that Dom has tested [56:45]; Ketogenic protocols for management of traumatic brain injuries [1:06:00]; Comparing the benefits and therapeutic uses of various medium-chain fatty acids—caprylic acid (C8), capric acid (C10), MCT oil, and coconut oil [1:08:45]; Nootropics, caffeine, and other stimulants [1:16:15]; Supplemental use of testosterone, DHEA, and creatine for muscle growth and performance [1:23:45]; Impact of fasted-state training on strength and performance [1:30:15]; Stacking exogenous ketones with MCTs for optimal effectiveness [1:33:30]; BCAA supplements during a fast for muscle preservation [1:35:45]; What app is Dom using to track his macros? [1:42:00]; Getting enough micronutrients while on a ketogenic diet [1:47:15]; Ideal macros and getting enough protein for strength training in ketosis [1:48:15]; Pros, cons, and ideal macros of one meal a day [1:51:15]; Dom’s take on “carb backloading” [1:54:45]; Dom’s take on “carb up” days for ketogenic dieters [2:01:00]; Dom’s thoughts on the carnivore diet and the paleolithic ketogenic diet [2:05:30]; Advantages of the ketogenic diet for extreme endurance athletes [2:10:30]; Impact on strength, power, and performance during the adaptation period of the ketogenic diet [2:14:00]; Fasted-state elevation in growth hormone and its impact on training [2:17:45]; Is it possible to build muscle on a ketogenic diet? [2:23:30]; Why Dom took a year off from weight training [2:28:00]; What does Dom do for cardio exercise? [2:30:45]; Protocols for hard training recovery [2:33:15]; Dom’s personal approach to fasting, time-restricted eating, and sleep [2:35:45]; People, books, and other resources that shaped Dom’s training and nutrition [2:38:45]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/domdagostinoama01 Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

28 MINJUN 22
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AMA with Dom D’Agostino, Ph.D., Part I of II: Ketogenic diet, exogenous ketones, and exercise

David Watkins, Ph.D.: A masterclass in immunology, monoclonal antibodies, and vaccine strategies for COVID-19

In this episode, David Watkins, professor of pathology at George Washington University, shares how insights from his HIV and Zika virus research could apply to SARS-CoV-2 protection strategies. David introduces monoclonal antibodies as an intervention to prevent and treat COVID-19 infection, and also discusses how they could be used as a hedge to vaccine development. Additionally, David’s immunology tutorial explains the innate and adaptive immune systems and their differentiated responses to viral infection. We discuss: Background and current interest in immunology [4:30]; Immunology 101—The innate and adaptive immune system [10:15]; Defining antibodies, importance of neutralizing antibodies, and serology testing for COVID-19 [19:00]; B cells—How they fight viruses, create antibodies, and fit into the vaccine strategy [25:00]; T cells—Role in the adaptive immune system and ability to kill infected cells to prevent viral spread [36:15]; Valuable lessons from HIV applied to SARS-CoV-2 [51:00]; Lessons taken from the hepatitis C success story [1:01:30]; Monoclonal antibodies, vaccines, and the most promising strategies for preventing and treating COVID-19 infection [1:04:45]; COVID-19 vaccines in development [1:19:00]; How David’s work with Zika virus informs his thinking on SARS-CoV-2 [1:25:20]; Why a vaccine for COVID-19 doesn’t need to be perfect to be effective [1:27:45]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/davidwatkins Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

97 MINJUN 15
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David Watkins, Ph.D.: A masterclass in immunology, monoclonal antibodies, and vaccine strategies for COVID-19

Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies

In this episode, Eileen White, Chief Scientific Officer at the Rutgers Cancer Institute, describes the fundamental role of autophagy in the maintenance of health and prevention of neurodegeneration, cancer, and other diseases. She also goes into detail about the paradoxical finding that autophagy may benefit an existing cancer cell and help it to survive—a discovery leading to new possibilities in cancer therapy. We also discuss fasting (and molecules that induce autophagy) and the critical need to decode the proper fasting “dose” in order to improve human health. We discuss: Eileen’s discovery thata specificoncogeneblocksapoptosis [3:40]; Defining apoptosis and its role in cancer prevention [10:00]; Howcancer cells use the autophagy pathway to survive [17:20]; Stressorsthat induce autophagy [29:15]; The importance of autophagy in the brain and liver[32:45]; The mechanisms that can trigger autophagy to support longevity[40:00]; Evidence for cancer treatment by blocking autophagy[42:30]; Types of cancer that are mostautophagy-dependent[46:45]; The autophagy paradox[52:40]; Finding a molecular signal for autophagy[59:15]; Current knowledge gaps around fasting as a tool for longevity[1:13:00]; Rapamycin, metformin, and other molecules that may induce autophagy[1:22:15]; How to study fasting and exercise as longevity tools[1:32:50]; The Nobel Prize for autophagy research[1:36:45]; Eileen’s future areas of research[1:38:25]; A fasting strategy for Alzheimer’s Disease prevention[1:49:25]; Future study of metabolism and autophagy[1:51:30]; and More. Learn more:https://peterattiamd.com/ Show notes page for this episode: https://peterattiamd.com/eileenwhite Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

118 MINJUN 8
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Eileen White, Ph.D.: Autophagy, fasting, and promising new cancer therapies

Normative errors—a conversation with my daughter about current events

In this episode, I sit down with my daughter to discuss the brutal death of George Floyd, and the aftermath we are watching unfold. Though I have no expertise in race relations, law enforcement, or police brutality, I do have some knowledge in the training of physicians, and it is that training of doctors that I’ve been thinking about lately as it may offer one small insight into this crisis. In this very short discussion, we speak about three types of errors in medicine (and medical training), how to distinguish between the two variants that are acceptable, and the one that is unacceptable. My question, ultimately, is if such a framework can be applied to law enforcement? Learn more:https://peterattiamd.com/ Subscribe to receive exclusive subscriber-only content:https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter:https://peterattiamd.com/newsletter/ Connect with Peter on Facebook | Twitter | Instagram.

22 MINJUN 4
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Normative errors—a conversation with my daughter about current events

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