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a16z Podcast

Andreessen Horowitz

611
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4.7K
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a16z Podcast

a16z Podcast

Andreessen Horowitz

611
Followers
4.7K
Plays
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About Us

The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!

Latest Episodes

Turning Open Source Developers Into Superfans

In this episode, we continue our community series with a recent discussion that applies to many kinds of community building. Today’s topic: How do you create a platform that people not only use, but tell their friends about? One that goes beyond just being useful and actually connects deeply with the user? In this discussion, which was recorded at our Crypto Startup School in April 2020, a16z General Partner Chris Dixon talked about building communities — specifically, communities of open-source developers — with GitHub cofounder Tom Preston-Werner. They discussed how to engage early users, how to turn them into your biggest advocates, how to create superfans, and more. Today, GitHub is the leading community for open-source developers and others. They also discuss in-person communities vs. distributed communities, a topic that is very top of mind today.

45 MIN2 d ago
Comments
Turning Open Source Developers Into Superfans

Journal Club: Slaying the Sleeper Cells of Aging with CAR T

with @jorgecondebio @andy23tran and @lr_bio On this episode of the a16z Journal Club we discuss new research using engineered T cells to attack and destroy the "sleeping" cells that build up as we age and underlie many age-related conditions. This research lays the groundwork for a possible therapy that, in addition to treating specific diseases like liver fibrosis, is broadly health-promoting and restorative as we age.

17 MIN3 d ago
Comments
Journal Club: Slaying the Sleeper Cells of Aging with CAR T

Working, Making, Creating in Public... and Private

with @nayafia @smc90 Communities are everything, but the word "members" is faceless. What if there's a better, more modern way to understand, support, and design for communities of all kinds -- whether open source, passion economy, or other groups coming together? Nadia Eghbal offers the latest research and insights from her new book, Working in Public: The Making and Maintenance of Open Source Software... but it's not all participatory, and it's not all public, either.

47 MIN1 w ago
Comments
Working, Making, Creating in Public... and Private

GPT-3: What's Hype, What's Real on the Latest in AI

with @smc90 @withfries2 Given all the recent buzz around the language model GPT-3 -- what is "it", how does it work, where does it fit into the arc of broader tech trends -- what's hype, what's real here? Are we really getting closer to artificial general intelligence? We cover all this and more and discuss broader implications for startups, incumbents, and the future of work too.

33 MIN1 w ago
Comments
GPT-3: What's Hype, What's Real on the Latest in AI

Taking the Pulse on Medical Device Security

with @AndreaCoravos, @beauwoods, and @omnivorousread Many don’t realize we even need to think about the possibility of security hacks when it comes to things like pacemakers, insulin pumps, and more. But when bits and bytes meet flesh and blood, security becomes literally a life or death concern. So what are the issues and risks we need to be aware of in exposing security vulnerabilities in connected biomedical devices? This conversation—with Beau Woods, Cyber Safety Innovation Fellow with the Atlantic Council, part of the I Am The Cavalrygrassroots security initiative, Founder/CEO ofStratigos Security; Andy Coravos, co-founder and CEO of Elektra Labs, advisor to the Biohacking Village at DEF CON (both of whom were formerly EIRs at the FDA); and a16z's Hanne Tidnam covers how we should begin to think about addressing these security issues in the biomedical device space. What are the frameworks that should guide our conversations, and how and when (and which!) stakeholders should b...

23 MIN3 w ago
Comments
Taking the Pulse on Medical Device Security

Journal Club: A New Path to Antibiotic Resistance

With Nathalie Balaban and @lr_bio Antibiotic resistance is an urgent problem, but many aspects of how bacteria acquire this ability to evade the drugs designed to target them are still mysterious. On this episode of the a16z bio Journal Club, Lauren Richardson interviews Professor Nathalie Balaban about her group’s research into the conditions that promote antibiotic resistance in patients suffering from life threatening infections and how to prevent it with carefully and rationally selected drug combinations.

17 MIN3 w ago
Comments
Journal Club: A New Path to Antibiotic Resistance

Cybercrime, Incorporated

with Joel de la Garza, Jonathan Lusthaus, and @omnivorousread Cybercrime is unfortunately as evergreen a topic as the problem itself—which is why we’re re-running this popular security episode all about the criminal industry of cybercrime from 2019. The idea of the cybercriminal as lone wolf or hobby hacker is no longer much of a reality. Instead, the business of cybercrime looks a lot more like a large, global technology business, with many of the same structures, challenges, and even casts of characters that legitimate businesses have. In this conversation, a16z’s Joel de la Garza, a16z operating partner for information security (formerly CSO of Box and head Citigroup’s Cyber Intelligence Center), and Hanne Tidnam, discuss with Jonathan Lusthaus, Director of the Human Cybercriminal Project at the University of Oxford, the evolution of cybercrime into a sprawling and sophisticated international industry.

36 MIN3 w ago
Comments
Cybercrime, Incorporated

How Transparent Pricing Drives Healthcare Change

with @MartyMakary and @julesyoo Dr. Marty Makary—surgical oncologist at Johns Hopkins University School of Medicine, and health policy and innovation expert—has long been a passionate advocate for transparent pricing in the healthcare system. We don’t talk enough (or really at all) about price in healthcare, says Makary (instead, we talk about cost). But shedding a light on prices in healthcare—from not just what those prices are but how prices are set and the value we all receive as consumers of the system overall—can help us measure quality in medicine, and be a driver for real behavioral change in the healthcare system, correcting many of the unintended consequences of a fee-for-service system like surprise billing or unnecessary medical procedures. In this conversation with a16z General Partner Julie Yoo, Makary and Yoo discuss what price transparency in the healthcare system could really do; how we can "steer" towards the good physicians who are not just highly skilled, bu...

29 MINJUL 16
Comments
How Transparent Pricing Drives Healthcare Change

Preserving Digital History: How to Close the Web's 'Memory Hole'

More than 98% of the information on the web is lost within 20 years, and huge gaps exist in our digital and cultural history. Zoran Basich and Alex Pruden of a16z talk to Brewster Kahle and Sam Williams, who are using different approaches to attack this problem. Brewster cofounded the Internet Archive, which is well known for creating the Wayback Machine that crawls a billion URLs every day. Sam cofounded Arweave, a company that uses decentralized crypto networks to store information forever. For both of them, this issue has implications that go far beyond just data storage. It touches on issues of censorship, government manipulation of information, and how historical context is necessary for well-functioning societies. They discuss how decentralized models offer the promise of building a next-generation web that works better for users.

47 MINJUL 14
Comments
Preserving Digital History: How to Close the Web's 'Memory Hole'

Alex Honnold on Human Performance (part 2) – Climbing and Entrepreneurship

In part 2 of our series on human performance, rock climber Alex Honnold talks about the risk, fear, and preparation around his free solo of El Cap... and the parallels it has with entrepreneurship.

18 MINJUL 11
Comments
Alex Honnold on Human Performance (part 2) – Climbing and Entrepreneurship

Latest Episodes

Turning Open Source Developers Into Superfans

In this episode, we continue our community series with a recent discussion that applies to many kinds of community building. Today’s topic: How do you create a platform that people not only use, but tell their friends about? One that goes beyond just being useful and actually connects deeply with the user? In this discussion, which was recorded at our Crypto Startup School in April 2020, a16z General Partner Chris Dixon talked about building communities — specifically, communities of open-source developers — with GitHub cofounder Tom Preston-Werner. They discussed how to engage early users, how to turn them into your biggest advocates, how to create superfans, and more. Today, GitHub is the leading community for open-source developers and others. They also discuss in-person communities vs. distributed communities, a topic that is very top of mind today.

45 MIN2 d ago
Comments
Turning Open Source Developers Into Superfans

Journal Club: Slaying the Sleeper Cells of Aging with CAR T

with @jorgecondebio @andy23tran and @lr_bio On this episode of the a16z Journal Club we discuss new research using engineered T cells to attack and destroy the "sleeping" cells that build up as we age and underlie many age-related conditions. This research lays the groundwork for a possible therapy that, in addition to treating specific diseases like liver fibrosis, is broadly health-promoting and restorative as we age.

17 MIN3 d ago
Comments
Journal Club: Slaying the Sleeper Cells of Aging with CAR T

Working, Making, Creating in Public... and Private

with @nayafia @smc90 Communities are everything, but the word "members" is faceless. What if there's a better, more modern way to understand, support, and design for communities of all kinds -- whether open source, passion economy, or other groups coming together? Nadia Eghbal offers the latest research and insights from her new book, Working in Public: The Making and Maintenance of Open Source Software... but it's not all participatory, and it's not all public, either.

47 MIN1 w ago
Comments
Working, Making, Creating in Public... and Private

GPT-3: What's Hype, What's Real on the Latest in AI

with @smc90 @withfries2 Given all the recent buzz around the language model GPT-3 -- what is "it", how does it work, where does it fit into the arc of broader tech trends -- what's hype, what's real here? Are we really getting closer to artificial general intelligence? We cover all this and more and discuss broader implications for startups, incumbents, and the future of work too.

33 MIN1 w ago
Comments
GPT-3: What's Hype, What's Real on the Latest in AI

Taking the Pulse on Medical Device Security

with @AndreaCoravos, @beauwoods, and @omnivorousread Many don’t realize we even need to think about the possibility of security hacks when it comes to things like pacemakers, insulin pumps, and more. But when bits and bytes meet flesh and blood, security becomes literally a life or death concern. So what are the issues and risks we need to be aware of in exposing security vulnerabilities in connected biomedical devices? This conversation—with Beau Woods, Cyber Safety Innovation Fellow with the Atlantic Council, part of the I Am The Cavalrygrassroots security initiative, Founder/CEO ofStratigos Security; Andy Coravos, co-founder and CEO of Elektra Labs, advisor to the Biohacking Village at DEF CON (both of whom were formerly EIRs at the FDA); and a16z's Hanne Tidnam covers how we should begin to think about addressing these security issues in the biomedical device space. What are the frameworks that should guide our conversations, and how and when (and which!) stakeholders should b...

23 MIN3 w ago
Comments
Taking the Pulse on Medical Device Security

Journal Club: A New Path to Antibiotic Resistance

With Nathalie Balaban and @lr_bio Antibiotic resistance is an urgent problem, but many aspects of how bacteria acquire this ability to evade the drugs designed to target them are still mysterious. On this episode of the a16z bio Journal Club, Lauren Richardson interviews Professor Nathalie Balaban about her group’s research into the conditions that promote antibiotic resistance in patients suffering from life threatening infections and how to prevent it with carefully and rationally selected drug combinations.

17 MIN3 w ago
Comments
Journal Club: A New Path to Antibiotic Resistance

Cybercrime, Incorporated

with Joel de la Garza, Jonathan Lusthaus, and @omnivorousread Cybercrime is unfortunately as evergreen a topic as the problem itself—which is why we’re re-running this popular security episode all about the criminal industry of cybercrime from 2019. The idea of the cybercriminal as lone wolf or hobby hacker is no longer much of a reality. Instead, the business of cybercrime looks a lot more like a large, global technology business, with many of the same structures, challenges, and even casts of characters that legitimate businesses have. In this conversation, a16z’s Joel de la Garza, a16z operating partner for information security (formerly CSO of Box and head Citigroup’s Cyber Intelligence Center), and Hanne Tidnam, discuss with Jonathan Lusthaus, Director of the Human Cybercriminal Project at the University of Oxford, the evolution of cybercrime into a sprawling and sophisticated international industry.

36 MIN3 w ago
Comments
Cybercrime, Incorporated

How Transparent Pricing Drives Healthcare Change

with @MartyMakary and @julesyoo Dr. Marty Makary—surgical oncologist at Johns Hopkins University School of Medicine, and health policy and innovation expert—has long been a passionate advocate for transparent pricing in the healthcare system. We don’t talk enough (or really at all) about price in healthcare, says Makary (instead, we talk about cost). But shedding a light on prices in healthcare—from not just what those prices are but how prices are set and the value we all receive as consumers of the system overall—can help us measure quality in medicine, and be a driver for real behavioral change in the healthcare system, correcting many of the unintended consequences of a fee-for-service system like surprise billing or unnecessary medical procedures. In this conversation with a16z General Partner Julie Yoo, Makary and Yoo discuss what price transparency in the healthcare system could really do; how we can "steer" towards the good physicians who are not just highly skilled, bu...

29 MINJUL 16
Comments
How Transparent Pricing Drives Healthcare Change

Preserving Digital History: How to Close the Web's 'Memory Hole'

More than 98% of the information on the web is lost within 20 years, and huge gaps exist in our digital and cultural history. Zoran Basich and Alex Pruden of a16z talk to Brewster Kahle and Sam Williams, who are using different approaches to attack this problem. Brewster cofounded the Internet Archive, which is well known for creating the Wayback Machine that crawls a billion URLs every day. Sam cofounded Arweave, a company that uses decentralized crypto networks to store information forever. For both of them, this issue has implications that go far beyond just data storage. It touches on issues of censorship, government manipulation of information, and how historical context is necessary for well-functioning societies. They discuss how decentralized models offer the promise of building a next-generation web that works better for users.

47 MINJUL 14
Comments
Preserving Digital History: How to Close the Web's 'Memory Hole'

Alex Honnold on Human Performance (part 2) – Climbing and Entrepreneurship

In part 2 of our series on human performance, rock climber Alex Honnold talks about the risk, fear, and preparation around his free solo of El Cap... and the parallels it has with entrepreneurship.

18 MINJUL 11
Comments
Alex Honnold on Human Performance (part 2) – Climbing and Entrepreneurship

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